Large-Scale Cohort Study on the Relationship Between Serum Lipid Concentrations and Risk of Cerebrovascular Disease Under Low-Dose Simvastatin in Japanese Patients With Hypercholesterolemia Sub-Analysis of the Japan Lipid Intervention Trial (J-LIT)
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- Nakaya Noriaki
- Nakaya Clinic
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- Kita Toru
- Kyoto University Graduate School of Medicine
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- Mabuchi Hiroshi
- Kanazawa University Graduate School of Medicine
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- Matsuzaki Masunori
- Yamaguchi University Graduate School of Medicine
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- Matsuzawa Yuji
- Sumitomo Hospital
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- Oikawa Shinichi
- Nippon Medical School
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- Saito Yasushi
- Chiba University Graduate School of Medicine
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- Sasaki Jun
- International University of Health and Welfare Graduate School
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- Shimamoto Kazuaki
- Sapporo Medical University School of Medicine
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- Itakura Hiroshige
- Ibaraki Christian University Chairman of Central Committee
書誌事項
- タイトル別名
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- Sub-Analysis of the Japan Lipid Intervention Trial (J-LIT)
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Background The Japan Lipid Intervention Trial was a nationwide cohort study of 52,421 hypercholesterolemic patients treated with open-labeled simvastatin for 6 years under standard clinical practices. Cerebrovascular disease (CVD) is one of the leading causes of death in Japan, but the effect of hypercholesterolemia on CVD has not been well established in Japanese patients. This study aimed to determine the relationship between the risk of CVD and serum lipid concentrations during treatment in Japan. Methods and Results Patients were treated with 5-10 mg/day of simvastatin and all, including those who discontinued simvastatin for any reason, had their lipid concentrations and incidence of CVD monitored for 6 years. Data of 41,088 patients were analyzed in this study, excluding those who had a history of coronary heart disease or CVD. The risk of cerebral infarction was higher in patients whose mean total cholesterol concentrations during treatment were ≥240 mg/dl, low-density lipoprotein cholesterol concentrations ≥160 mg/dl, triglycerides ≥150 mg/dl and high-density lipoprotein cholesterol concentrations <40 mg/dl. There was no obvious correlation between cerebral hemorrhage and serum lipid concentrations. Conclusion Improvement of serum lipid concentrations is important for reducing the incidence of cerebral infarction. (Circ J 2005; 69: 1016 - 1021)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 69 (9), 1016-1021, 2005
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680081213312
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- NII論文ID
- 110002703832
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- NII書誌ID
- AA11591968
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- COI
- 1:STN:280:DC%2BD2MvlvVajsQ%3D%3D
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- ISSN
- 13474820
- 13469843
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- PubMed
- 16127179
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
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- 使用不可