Prognostic Value of Serum Amyloid A Protein in Patients With Acute Myocardial Infarction Katayama Toshiro Nakashima Hiroshi Takagi Chisa Honda Yukiharu Suzuki Shin Iwasaki Yoshihiro Yano Katsusuke 社団法人日本循環器学会 Circulation Journal 13469843 69 10 1186 1191 2005-09-20 Background The relationship between plasma levels of serum amyloid A protein (SAA) concentrations and clinical course (including mortality) was investigated in patients with acute myocardial infarction (AMI). Methods and Results The study enrolled 280 consecutive AMI patients who were admitted within 10h of onset and were successfully reperfused by primary percutaneous coronary intervention. Plasma SAA concentrations were evaluated at 24h after onset. The threshold of the upper quintile (325μg/dl) was used to divide patients into 2 groups : either a high SAA (H group : &ge;325μg/dl; n=56) or low SAA (L group : <325μg/dl; n=224). (I) Left ventricular (LV) ejection fraction in the chronic phase was significantly less in the H group than in the L group (52±14% vs 57±13%, p=0.03). (II) There were significantly more major complications in the H group than in the L group (cardiac rupture : p=0.0007, cardiogenic shock : p<0.0001; subacute thrombosis : p=0.0007; cardiac death : p=0.0003). (III) Multivariate analysis identified SAA as an independent predictor of 6-month mortality in AMI patients (risk ratio : 5.8, 95%confidence interval : 1.3-27.7, p=0.03). Conclusions In the setting of AMI, plasma SAA concentrations may be closely related to LV systolic dysfunction and poor patient outcomes, including mortality. 2005-09-20 110002703863 AA11591968 ENG CJPref NII-ELS J-STAGE 3 3 Prognostic Value of Serum Amyloid A Protein in Patients With Acute Myocardial Infarction Katayama Toshiro Nakashima Hiroshi Takagi Chisa Honda Yukiharu Suzuki Shin Iwasaki Yoshihiro Yano Katsusuke Japanese Circulation Society Circulation journal : official journal of the Japanese Circulation Society Background The relationship between plasma levels of serum amyloid A protein (SAA) concentrations and clinical course (including mortality) was investigated in patients with acute myocardial infarction (AMI). Methods and Results The study enrolled 280 consecutive AMI patients who were admitted within 10h of onset and were successfully reperfused by primary percutaneous coronary intervention. Plasma SAA concentrations were evaluated at 24h after onset. The threshold of the upper quintile (325μg/dl) was used to divide patients into 2 groups : either a high SAA (H group : &ge;325μg/dl; n=56) or low SAA (L group : <325μg/dl; n=224). (I) Left ventricular (LV) ejection fraction in the chronic phase was significantly less in the H group than in the L group (52±14% vs 57±13%, p=0.03). (II) There were significantly more major complications in the H group than in the L group (cardiac rupture : p=0.0007, cardiogenic shock : p<0.0001; subacute thrombosis : p=0.0007; cardiac death : p=0.0003). (III) Multivariate analysis identified SAA as an independent predictor of 6-month mortality in AMI patients (risk ratio : 5.8, 95%confidence interval : 1.3-27.7, p=0.03). Conclusions In the setting of AMI, plasma SAA concentrations may be closely related to LV systolic dysfunction and poor patient outcomes, including mortality. Katayama Toshiro Department of Cardiovascular Medicine and Course of Medical and Dental Science, Graduate School of Biomedical Science, Nagasaki University Nakashima Hiroshi Department of Cardiology, Nagasaki Citizens Hospital Takagi Chisa Department of Cardiology, Nagasaki Citizens Hospital Honda Yukiharu Department of Cardiology, Nagasaki Citizens Hospital Suzuki Shin Department of Cardiology, Nagasaki Citizens Hospital Iwasaki Yoshihiro Department of Cardiology, Nagasaki Kouseikai Hospital Yano Katsusuke Department of Cardiovascular Medicine and Course of Medical and Dental Science, Graduate School of Biomedical Science, Nagasaki University