Effects of Capsinoid on Serum and Liver Lipids in Hyperlipidemic Rats

We compared the effects of capsinoid, a non-pungent component, on serum and liver lipids, with that of synthetic capsaicin in hyperlipidemic rats Male Wistar rats of 9 wk old were divided into 4 groups a control group receiving a high-fat diet containing 1% cholesterol, and capsaicin, capsinoid-I and capsinoid-II groups supplemented with 0 1 mmol of N-pelargonylvanillylamide (synthetic capsaicin), and 0 1 mmol and 1 0 mmol of capsinoid (capsiate dinydrocapsiate=63 37) per kg of control diet, respectively All groups were pair-fed for 4 wk Compared with the control group, serum lipid levels in both capsinoid groups and liver lipid contents in the capsinoid-II group showed the same reduction as that of the capsaicin group In the capsaicin and capsinoid-I groups, fatty acid synthase (FAS) activities were lower and hepatic triacylglycerol lipase (HTGL) [EC 3 1 1 3] activities tended to be higher than those of control group Lipoprotein lipase (LPL) [EC 3 1 1 34] activity in adipose tissue was higher in the capsaicin and capsinoid-II groups than in the control group These results showed that capsinoid can improve serum and liver lipid metabolism comparable to synthetic capsaicin