Structure of neuromuscular junctions during muscle fiber degeneration and regeneration induced by bupivacaine hydrochloride. :
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- KASUGA,Norikatsu
- Aichi University of Education
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- HIRANO,Tomoe
- Aichi University of Education
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- NISIZAWA,Tomie
- Tottori University
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- TAKEKURA,Hiroaki
- National Institute of Fitness and Sports in Kanoya
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We observed the morphological features of the neuromuscular junctions following a single direct injection of 0.5% bupivacaine hydrochloride(Marcaine)into extensor digitorum longus of young adult female Fischer344 rats induced muscle fiber degeneration and regeneration. Four obvious structural degeneration and regeneration pattern were observed after treatment with bupivacaine : (1)Z-line loss fiber, (2)opaque(hyper-contracted)fiber, (3)empty sarcoplasm(myofibrils were totally disrupted)fiber, (4)necrotic fiber. Until 4 days after BPVC injection the degenerated fibers increased significantly. After 6 days, regenerating fibers appeared whereas the endplate spread of cholinesterase and planar neuromuscular junction area reached the smallest level at 4 days and 6 days, respectively. On electron microscopy the most striking findings in the early phase were the focal disappearance of the secondary synaptic cleft and Z-line loss with no destruction on the peripheral nerves(terminal branch axons). 14 days after muscle injury, regenerating fibers characterized by a redeveloped the secondary synaptic cleft and Z-line appeared. These observations suggest that the neuromuscular junctions regeneration depends on the remodeling of synaptic membrane systems.
収録刊行物
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- Advances in exercise and sports physiology
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Advances in exercise and sports physiology 6 (4), 127-,
Japan Society of Exercise and Sports Physiology
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詳細情報 詳細情報について
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- CRID
- 1541980095202982912
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- NII論文ID
- 110002705562
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- NII書誌ID
- AA11107566
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- 本文言語コード
- en
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- データソース種別
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- NDL-Digital
- CiNii Articles