Molecular pathology of human cerebral malformations

• Masashi Mizuguchi

抄録

ABSTRACT Molecular pathogenesis of human cerebral malformations is briefly reviewed from a neuro-pathologic viewpoint, with emphasis on holoprosencephaly and neuronal migration disorders. Immunopathologic approaches are useful in elucidating the essential pathomechanism of these anomalies. In alobar holoprosencephaly, for instance, immunostaining for glial fibrillary acidic protein clarifies the pathologic significance of the leptomeningeal glioneuronal heterotopia along the ventral prosencephalic surface. In type 1 lissencephaly and subcortical laminar heterotopia, immunohistochemistry for the causative gene products revealed the temporal and spatial pattern of their localization in the normally developing cerebrum, as well as their reduction in these disorders.

収録刊行物

• 日本先天異常学会会報

  日本先天異常学会会報 43 (1), 22-28, 2003

  日本先天異常学会

キーワード

• holoprosencephaly
• leptomeningeal glioneuronal heterotopia
• lissencephaly
• neuronal migration
• subcortical laminar heterotopia
• ventral induction

詳細情報

• CRID: 1390851872316611840
• NII論文ID: 110002785596
• NII書誌ID: AN10066760
• ISSN: 09143505
• ISSN: 24331503
• ISSN: 17414520
• ISSN: 00372285
• DOI: 10.24540/cgafa.43.1_22
• DOI: 10.1111/j.1741-4520.2003.tb01023.x
• NDL書誌ID: 6541635
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6541635
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1741-4520.2003.tb01023.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1741-4520.2003.tb01023.x
• Web Site: https://search.jamas.or.jp/link/ui/2003250075
• 本文言語コード: en
• データソース種別:
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  • NDL
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