Systemic Lupus Erythematosus and Congenital Anomalies, Focusing on Neonatal Lupus Erythematosus and Anti‐SS‐A/SS‐B Antibodies*

• 橋本 博史

• 高崎 芳成

• 官川 薫

書誌事項

タイトル別名

• Systemic Lupus Erythematosus and Congenital Anomalies, Focusing on Neonatal Lupus Erythematosus and Anti-SS-A/SS-B Antibodies*
• Systemic lupus erythematosus and congen

抄録

ABSTRACT SLE is a representative autoimmune disease which develops preferentially in women of childbearing age. Its frequent occurrence makes the coincidence of SLE and pregnancy an important clinical problem. SLE is thought to be multifactorial dis- ease. A familial prevalence was found to be 3% which was significantly higher when compared with Japanese prevalence of SLE. When women with SLE become pregnant, the fetus is at high risk and is adversely affected showing the high prevalence of fetal loss. Antiphospholipid antibodies were thought to be one of the causative factors. Ne- onetal lupus erythematosus (NLE) including lupus like skin lesions and congenital complete heart block (CCHB) is associated with maternal anti-SS-A and SS-B antibodies. The disease resolves with normalization of the maternal antibodies by the 8th month after delivery with the exception of the CCHB which is almost universally irriversible. When the sera from 4 maternal patients with NLE and 32 patients with normal delivery were analyzed by immunoblotting using recombinant 60 and 52 kD SS-A, and SS-B purified from calf thymus extract, the frequency of anti-52 kD SS-A and SS-B in patients with NLE was significantly higher than that of patients with normal delivery. Anti-SS- A/SS-B antibodies may react with the SS-A/SS-B antigens in fetal heart tissue as fetal levels of IgG increases which is almost simultaneously as when the SS-A/SS-B antigens appear in the fetal heart tissue. The pathogenesis of tissue damage mediated by autoimmune mechanisms specifically dependent on the biology of pregnancy is recognized to be due to passively acquired autoimmune injury.

収録刊行物

• 日本先天異常学会会報

  日本先天異常学会会報 32 (4), 301-307, 1992

  日本先天異常学会

キーワード

• Developmental Biology
• Embryology
• General Medicine
• Pediatrics, Perinatology and Child Health

詳細情報

• CRID: 1390007369930279936
• NII論文ID: 110002786720
• NII書誌ID: AN10066760
• ISSN: 09143505
• ISSN: 24331503
• ISSN: 17414520
• ISSN: 00372285
• DOI: 10.24540/cgafa.32.4_301
• DOI: 10.1111/j.1741-4520.1992.tb00256.x
• NDL書誌ID: 3816057
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3816057
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1741-4520.1992.tb00256.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1741-4520.1992.tb00256.x
• Web Site: https://search.jamas.or.jp/link/ui/1994062507
• 本文言語コード: en
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