Pathogenesis of Congenital Diaphragmatic Hernia Induced by Transplacental Infusion of Bisdiamine into Rats

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  • Pathogenesis of Congenital Diaphragmati

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ABSTRACT We studied the pathogenesis of congenital posterolateral diaphragmatic hernia induced by bisdiamine in rats. The frequency of live fetuses with left congenital diaphragmatic hernia (which resembles a hernia through the foramen of Bochdalek in man) was high (78.4%) when pregnant rats were administered bisdiamine by gavage once at a dose of 400 mg/kg on day 9 of pregnancy. Then the bisdiamine-treated rat fetuses were examined at successive developmental stages. Histopathological observation revealed that 1) in the control fetus on day 14 of pregnancy, the mesothelial cells lining the pleural aspect of the pleuroperitoneal fold were eventually clustered close to the pleuroperitoneal opening, giving the appearance of a high wave lapping the shore; 2) in the affected fetus on day 14 of pregnancy, the mesothelial cells of the pleural aspect of the fold were scarce; 3) in the affected fetuses during days 14-16 of pregnancy, primary lung hypoplasia was seen. On day 19 of pregnancy, no remarkable differences in the gross appearance of the right lung were found between the affected and control fetuses. Each lung (right and left) of the affected embryos may be considered to have the potential for further growth and development. The development of the mesothelium of the pleura may be greatly influenced by the growth and enlargement of the thorax (mainly the lung), and a retardation of lung growth near the time of pleuroperitoneal canal closure may induce the hernia in diaphragm.

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