Effects of Extract from Lactobacillus casei on Blood Pressure, Cerebral Stroke Lesions, and Life Span in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)

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  • 乳酸桿菌菌体抽出物の脳卒中易発症性自然発症高血圧ラットの血圧,脳卒中病変および生存日数に及ぼす影響
  • ニュウサン カンキン キンタイ チュウシュツブツ ノ ノウソッチュウ イハッシ

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Abstract

The effects of long-term oral feeding of an extract from Lactobacillus casei (LEx), which has antihypertensive activity, on blood pressure, cerebral stroke lesions, and life span of stroke-prone spontaneously hypertensive rats (SHRSP) were studied. The usual elevation in blood pressure was depressed by oral intake of 1 or 10 mg of extract per kilogram of body weight daily for 11 weeks. LEx did not affect body weight or food intake. In the control group, the water intake increased with age, but in the group given LEx, water intake was unchanged. The mean life span of the group given 10 mg of LEx per kilogram of body weight daily was significantly longer than that of the control group. Differences in the organ weights of the control and treated groups were not significant except for the heavier kidneys in the treated group week 5 after treatment began. In rats given 10 mg of LEx per kilogram of body weight daily, the incidence of cerebral stroke lesions was less than in the control group. LEx inhibited fibrinoid degeneration of the arteriola. These results suggest that the prolongation of life span resulted from suppression by LEx of the usual elevation of blood pressure in these rats and the subsequent reduction in the incidence of vascular lesions in the cerebrum, organs, and tissues.

Journal

  • Nippon Nōgeikagaku Kaishi

    Nippon Nōgeikagaku Kaishi 69 (5), 557-563, 1995

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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