Diffusion MRIを用いた生体内水分子の制限拡散に関する研究

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タイトル別名
  • Study of Restricted Water Diffusion in Biological Tissue by Diffusion Magnetic Resonance Imaging
  • Diffusion MRI オ モチイタ セイタイナイ ミズブンシ ノ セイゲン カクサン ニ カンスル ケンキュウ

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The exact mechanisms underlying the relationship between water diffusion and tissue microstructure remain largely unknown. Theoretically, signal decay by a motion probing gradient (MPG) in diffusion magnetic resonance imaging (MRI) represents the monoexponential form. However, it has been reported that in diffusion MRI experiments using high b values, the diffusion signal decay in biological tissues is not monoexponential, but is more accurately biexponential. Although unverified, it is assumed that the slow and fast diffusion components are assigned to the intra- and extracellular space respectively. In this study, we measured the fractions of fast and slow diffusion components of leukemic cells (TCC-S cells) using diffusion MR spectroscopy, and we compared the two diffusion components with the volume fractions. The results show that the assignment of diffusion components to volume fractions is not correct. The difference between the volume fractions and the fractions of components is attributed to the exchange of water molecules between two compartments through the cell membrane. To clarify the exact effects of the exchange of water molecules to MRI signals, we used a finite difference diffusion simulation model and were able to estimate the water exchange rate through the cell membrane.

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