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- 柴田 克己
- 大阪国際女子大学人間科学部人間健康科学科
書誌事項
- タイトル別名
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- Measurement of 6-Aminonicotinamide, an Antagonist of Niacin, by High-performance Liquid Chromatography
- ニコチンアミド ノ キッコウタイ 6 アミノニコチンアミド ノ コウソク エキ
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抄録
The author has developed the HPLC measurement of 6-aminonicotinamide, which is the most powerful antagonist of niacin. The analytical method for the measurement of 6-aminonicotinamide used a 7-ODS-L column (250 mm × 4.6 mm I. D. , particle size 7 μm) eluted with 10 mM potassium dihydrogenphosphate-acetonitrile (96 : 4, v/v, pH was adjusted to 3.0 by addition of concentrated phosphoric acid) at a flow-rate of 1.0 ml/min. The UV detector was set at 266 nm. The column temperature was maintained at 25℃. Under the conditions, 6-aminonicotinamide was eluted at about 4 min and the simultaneous measurements of nicotinamide, N^<-1>-methyl-2-pyridone-5-carboxamide and N^<-1>-methyl-4-pyridone-3-carboxamide were possible. The detection limit was 4 pmol at a signal-to-noise ratio of 5 : 1. The total time required for one analysis was around 15 min. The 6-aminonicotinamide in the liver and urine of the rats fed with a diet being added 6-aminonicotinamide was measured as test food samples containing 6-aminonicotinamide.
収録刊行物
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- ビタミン
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ビタミン 67 (9), 493-497, 1993
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390282680808739200
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- NII論文ID
- 110002844553
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 3843266
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可