Ehrlich腹水ガン細胞のコハク酸脱水素酵素およびDPNH-ジアホラーゼ活性 : DPNH-ジアホラーゼ活性と細胞分裂との関係

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タイトル別名
  • THE RELATION OF ACTIVITIES OF DPNH-DIAPHORASE AND SUCCINIC DEHYDROGENASE TO MITOSIS IN EHRLICH'S ASCITES TUMOR CELLS
  • Ehlrich腹水ガン細胞のコハク酸脱水素酵素およびDPNH-ジアホラーゼ活性
  • Ehlrich フクスイ ガン サイボウ ノ コハクサン ダツスイソ コウソ オヨビ DPNH-ジアホラーゼ カッセイ

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It has been reported that succinic dehydrogenase activity in cancer cells was low, whereas DPNH-diaphorase activity was high. However, little is known about the relation of the enzymatic activities to mitosis in cancer cells. We have carried out experiments to find out any relation of these enzymes to mitois using histochemical techniques to demonstrate activities of the two flavin enzymes, and a phase contrast microscopical technique to observe the nuclear states. Succinic dehydrogenase activity in the cancer cells was too low to prove the relation of the activity to the state of mitosis. About ten percent of the total cells was found to have DPNH-diaphorase activity. The most cells with DPNH-diaphorase activity were in state of mitosis, while cells having no activity were in resting state. From these results, we concluded that DPNH-diaphorase has some relation to cell mitosis.

収録刊行物

  • ビタミン

    ビタミン 25 (1), 35-40, 1962

    公益社団法人 日本ビタミン学会

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