ホモパントテン酸のパントテン酸拮抗作用について

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タイトル別名
  • THE ANTAGONISTIC ACTION OF HOMOPANTOTHENIC ACID AGAINST PANTOTHENIC ACID
  • ホモパントテンサン ノ パントテンサン キッコウ サヨウ ニ ツイテ

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抄録

The action of homopantothenic acid, HOCH_2C(CH_3)_2CHOHCONH(CH_2)_3COOH, a derivative of γ-aminobutyric acid, and its hydroxy-forms was examined using lactobacilli and chick. These compounds showed a pronounced competitive antagonistic action for Lactobacillus arabinosus 17-5 and Leuconostoc mesenteroides P-60. When the 50% growth inhibition of homopantothenic acid was used as the index, an inhibition ratio of 150 was obtained. In the chick given 1mg/kg a day of pantothenic acid, oral administration of more than 2g/kg of homopantothenic acid induced pantothenic acid deficiency and reduction of liver CoA. These changes could be reversed by administration of pantothenic acid. This antagonistic effct of homopantothenic acid against pantothenic acid would be attributed to an inhibitory action in the pathway of biosynthesis from pantothenic acid to CoA.

収録刊行物

  • ビタミン

    ビタミン 32 (2), 245-259, 1965

    公益社団法人 日本ビタミン学会

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