ホモパントテン酸にかんする研究 : (III)ホモパントテン酸の電気生理学的検討
書誌事項
- タイトル別名
-
- STUDIES ON HOMOPANTOTHENIC ACID : (III) ELECTROPHYSIOLOGICAL INVESTIGATION OF HOMOPANTOTHENIC ACID
この論文をさがす
抄録
The effects of homopantothenic acid (HOPA) on the brain were invetigated electrophysio-logically. Local application and intra-arterial administration of the drug did not affect the trans-callosal potentials of the cats anesthetized with sodium pentobarbital. This suggests that the action of HOPA in the central nervous system does not depend upon γ-aminobutyric acid released from HOPA itself. The spontaneous EEG of the unanesthetized rabbits restrained stereotaxically was slightly changed into the alert pattern by HOPA. The intra-venous administ-ration of 500 mg/kg of HOPA did not antagonized pentylenetetrazol or picrotoxin induced seizures, but when 5 mg/kg of HOPA was administered intra-cisternally, these seizure discharges were arrested. The fact shows that HOPA hardly passes through the blood brain barrier.
収録刊行物
-
- ビタミン
-
ビタミン 33 (6), 609-614, 1966
公益社団法人 日本ビタミン学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205784824064
-
- NII論文ID
- 110002865471
-
- ISSN
- 2424080X
- 0006386X
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可