光学活性固定相を用いた逆相高速液体クロマトグラフィーによるカルボキシル基を有する医薬品の光学分割

DOI NDLデジタルコレクション Web Site Web Site 被引用文献1件 参考文献9件

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タイトル別名
  • Optical resolution of carboxylic drugs by reversed phase HPLC using chiral stationary phases.
  • コウガク カッセイ コテイソウ オ モチイタ ギャクソウ コウソク エキタイ

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抄録

The influences of achiral factors upon the retention and enantioselectivety of N-3, 5-dinitrobenzoyl derivatives of baclofen (4-amino-3-p-chlorophenylbutyric acid), a skeletal muscle relaxant, and DP-1904, a novel thromboxane A2 synthetase inhibitor, using three kinds of chiral stationary phases (long alkyl spacer-; LA-, short alkyl spacer-; SA- and helical-; Hel- type CSPs) have been examined. Mobile phases of organic solvent-aqueous phosphate buffer were used and the effects of organic solvent concentration, pH and the addition of achiral ion-pairing agents were studied. As a result, optimum ranges of enantioselectivities occured at each pH and contents of organic solvents except for short alkyl chain spacer type CSP. And we observed a linear relationship between the contents of organic solvents and In k' (k'=capacity factor). In the case of LA-CSP, the addition of achiral ion-pairing reagents (alkyltrimethylammonium phosphate) was effective. The increase in the concentration and the chain length of alkyl portion of the ion-pairing reagent gave increased retention and enantioselectivity for N 3, 5-dinitrobenzoyl derivatives of baclofen on LA-CSP. These results suggest that enantiomeric separation using HPLC can be improved by achiral factors.

収録刊行物

  • 分析化学

    分析化学 41 (9), 419-424, 1992

    公益社団法人 日本分析化学会

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