The .BETA.3-Adrenoceptor-Mediated Relaxation Induced by Dopamine in Guinea Pig Taenia Caecum.

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  • Akimoto Yurie
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
  • Horinouchi Takahiro
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
  • Tanaka Yoshio
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
  • Koike Katsuo
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences

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The mechanisms of the β-adrenoceptor-mediated relaxation induced by dopamine in guinea pig taenia caecum were examined. The relaxant response to dopamine was unaffected by propranolol (10-8 - 10-5 M) or phentolamine (10-8 - 10-5 M). Atenolol (3 × 10-7 - 3 × 10-4 M), butoxamine (10-7 - 10-4 M), prazosin (10-8 - 10-5 M), yohimbine (10-8 - 10-5 M), SCH 23390 (10-8 - 10-5 M) and haloperidol (10-8 - 10-5 M) had no effect on the potency of dopamine. The response to dopamine was antagonized in a concentration-dependent manner by bupranolol (3 × 10-6 - 3 × 10-5 M), and Schild plot of the data revealed the pA2 value of 5.55 and the slope of the regression line was 1.13. These results suggest that the relaxant response to dopamine in the guinea pig taenia caecum is mainly mediated by the β3-adrenoceptors.<br>

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