Electrical Properties of Colonic Smooth Muscle in Spontaneously Non-Insulin-Dependent Diabetic Rats.
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- IMAEDA Kenro
- Department of Physiology Nagoya City University Medical School
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- TAKANO Hiromichi
- Department of Physiology Nagoya City University Medical School
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- KOSHITA Makoto
- Department of Physiology Nagoya City University Medical School
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- YAMAMOTO Yoshimichi
- Department of Physiology Nagoya City University Medical School
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- JOH Takashi
- Internal Medicine I, Nagoya City University Medical School
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- SUZUKI Hikaru
- Department of Physiology Nagoya City University Medical School
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抄録
Electrical properties of colonic smooth muscle were investigated in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a model animal for spontaneous non-insulin-dependent diabetes mellitus (NIDDM), and the results were compared with those obtained from the Long-Evans Tokushima Otsuka (LETO) rat, a control of OLETF rat. At experiments (aged 60-80 weeks), blood glucose level was about 171 mg/dl in LETO rats and 370 mg/dl in OLETF rats. Feces in the colon were restricted to the proximal region in LETO rats and distributed widely in the whole colon in OLETF rats. In both LETO and OLETF rats, the circular smooth muscle strips of the isolated distal colon revealed two types of spontaneous electrical response, slow wave and transient hyperpolarization . The resting membrane potential was smaller in OLETF rats than in LETO rats by about 3 mV, but it was not positively related with the blood glucose level. The amplitude of hyperpolarization produced by noradrenaline (NA) was smaller in OLETF rats than in LETO rats. Transmural nerve stimulation evoked a non-adrenergic, non-cholinergic (NANC) inhibitory junction potential (i.j.p.) in both LETO and OLETF rats ; the amplitude of the i.j.p.was smaller in OLETF rats than in LETO rats, while the latency of the i.j.p.was longer in OLETF rats than in LETO rats. Thus, in the distal colon, NIDDM may cause a depolarization of the membrane, an attenuation of NANC inhibitory transmission and a reduction in reactivity of adrenoceptors to NA. These results suggest that the constipation appearing with diabetes mellitus involves dysfunction of both the enteric autonomic nerves and the smooth muscles in the colon.
収録刊行物
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- Journal of Smooth Muscle Research
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Journal of Smooth Muscle Research 34 (1), 1-11, 1998
日本平滑筋学会
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詳細情報 詳細情報について
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- CRID
- 1390001205055684992
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- NII論文ID
- 110002929769
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- NII書誌ID
- AN10364204
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- COI
- 1:CAS:528:DyaK1MXisVKksw%3D%3D
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- ISSN
- 18848796
- 09168737
- http://id.crossref.org/issn/09168737
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- PubMed
- 9866112
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可