心筋組織Krebs-回路に及ぼすAnoxiaの影響に就て : 特にCO腹腔内注入法による実験的研究

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  • Effect of Anoxia on the Krebs Cycle of the Rat Myocardium : Especially, An Experimental Study by Intraperitoneal CO-Administration
  • 必筋組織Krebs回路に及ぼすAnoxiaの影響に就て-特にCO腹腔内注入法による実験的研究
  • ヒツキン ソシキ Krebs カイロ ニ オヨボス Anoxia ノ エイキョウ ニ シュウテ - トクニ CO フククウ ナイ チュウニュウホウ ニ ヨル ジッケンテキ ケンキュウ

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In order to clarify the changes of the Krebs cycle occurring in myocardium working under conditions of anoxia, the capacities of oxidizing various substrates related to the cycle were studies in myocardial homogenates removed from rats killed after exposure to low pressure (310 mmHg) and CO-poisoning.As the method of the experimental CO-poisoning, the method of the intraperitoneal CO-administration inaugurated by T. Ishikawa in experiments on mouse and rabbits, was applied on a rat. For measuring the oxidizing capacity of a tissue, the Thunberg-tube was employed and the methylenblue decoloring time was assessed, to which the sodium salt, respectively, of lactate, pyruvate, citrate and succinate was added as substrates.

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