Platelet Activity is a Biomarker of Cardiac Necrosis and Predictive of Untoward Clinical Outcomes in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Stenting
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- Yip Hon-Kan
- Division of Cardiology, Chang Gung Memorial Hospital
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- Chang Li-Teh
- Basic Science, Nursing Department, Meiho Institute of Techology
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- Sun Cheuk-Kwan
- Department of General Surgery, Chang Gung Memorial Hospital
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- Chen Mien-Cheng
- Division of Cardiology, Chang Gung Memorial Hospital
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- Yang Cheng-Hsu
- Division of Cardiology, Chang Gung Memorial Hospital
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- Hung Wei-Chin
- Division of Cardiology, Chang Gung Memorial Hospital
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- Hsieh Yuan-Kai
- Division of Cardiology, Chang Gung Memorial Hospital
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- Fang Chih-Yuan
- Division of Cardiology, Chang Gung Memorial Hospital
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- Hang Chi-Ling
- Division of Cardiology, Chang Gung Memorial Hospital
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- Wu Chiung-Jen
- Division of Cardiology, Chang Gung Memorial Hospital
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- Chang Hsueh-Wen
- Department of Biological Sciences, National Sun Yat-Sen University
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Abstract
Background The relationship between platelet activity and myocardial injury in patients with ST-segment elevated (ST-se) acute myocardial infarction (AMI) remains unclear. This study tested the hypothesis that platelet activity (expressed by CD62p) is enhanced and predictive of both the extent of myocardial damage and 30-day clinical outcome in patients with ST-se AMI undergoing primary coronary stenting. Methods and Results Platelet CD62p expression prior to coronary angiographic was prospectively measured using flow cytometry in 45 consecutive patients with AMI undergoing primary coronary stenting. The CD62p expression was also evaluated in 20 healthy and 20 at-risk control subjects. The CD62p expression was significantly higher in AMI patients than in healthy and at-risk control subjects (all p values <0.0001). Patients with high CD62p expression (≥8%) had significantly higher creatine kinase-MB (p<0.0001) levels, higher incidence of cardiogenic shock (p=0.009) upon presentation, significantly lower left ventricular ejection fraction (p=0.0003), and significantly higher incidence of 30-day composite major adverse clinical outcomes (MACO) (advanced congestive heart failure ≥class 3 or 30-day mortality) (p<0.0001) than those patients with low CD62p expression (<8%). Multiple stepwise logistic regression analysis demonstrated that only high CD62p expression (≥8%) was an independent predictor of 30-day MACO (all p<0.0001). Conclusions Platelet activation was significantly increased in patients with ST-se AMI. Initial CD62p expression was independently associated with extent of myocardial damage and 30-day MACO. (Circ J 2006; 70: 31 - 36)<br>
Journal
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- Circulation Journal
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Circulation Journal 70 (1), 31-36, 2006
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390282680082184064
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- NII Article ID
- 110002978456
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
- http://id.crossref.org/issn/13469843
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed