濃厚カルシウムおよびリン酸塩水溶液による象牙質齲蝕部位の再石灰化 Remineralization of Root Lesions with Concentrated Calcium and Phosphate Solutions

In vitroにおいて,1 mol/Lリン酸塩溶液(pH9)と1 mol/Lカルシウム溶液(pH6)によるエナメル質齲蝕部位の連続的処理は再石灰化に有効でないことが報告されている.再石灰化におけるイオンの拡散過程の解析から,カルシウム溶液をリン酸溶液よりアルカリ性にした方が,Caイオンの齲蝕部位への拡散が促進されることがわかった.そこで,本研究では,アルカリ性のカルシウム溶液を用いて,in vitroにおける象牙質齲蝕部位の再石灰化を試みた所,以下の結果が得られた. 1) コントロール群においては,象牙質の表面に若干の再石灰化が観察された. 2) 実験群においては,表面から40 μm以内において石灰化量が有意に増加した.(p<0.05) 3) 前報の結果と異なり,象牙質表面に厚い沈殿物はみられなかった.

Remineralization of enamel lesions in vitro by use of sequential treatments with an alkaline (pH 9) phosphate (1 mol/L) solution and slightly acidic (pH 6) calcium (1 mol/L) solution was reported to be relatively ineffective. An analysis of the diffusion processes that may occur during the remineralization treatments suggested that the driving force for diffusion of Ca into the lesion can be increased by making the calcium solution more alkaline than the phosphate solution. In the present study this modified treatment procedure was evaluated for remineralizing root lesions in vitro. Results show that (1) in the control group there was a slight increase in mineral density in the surface region of the lesion, (2) in the experimental group there were significant (p<0.05) increase in mineral content in the outer 40 μm of the lesion, and (3) in contrast to the finding reported previously, thick mineral deposits on the surface of the root were not observed.