Immunohistochemical Study on Epithelialization of the Fascial Flap in the Oral Cavity of Rats Nagata Natsuki Inokuchi Tsugio Ikeda Hisazumi Elshal Elsherbini Elazazy 特定非営利活動法人日本臨床口腔病理学会 Oral medicine & pathology 13420984 3 1 13 20 1998-06 The immunohistochemical expressions of epidermal growth factor receptor (EGFR) and Proliferating Cell Nuclear Antigen (PCNA) were studied in the epithelialization process of bare flaps, the fascial flap and the deepithelialized mucoperiosteal flap, used for reconstruction of the oral mucosa in rat models. The intense expression of EGFR and PCNA was detected in the tip area of the migrating epithelium during the early period of the healing process in both flaps, and differing distributions of EGFR and PCNA positive cells were identified. In the fascial flap, a significantly high positive rate of EGFR was detected in comparison with the deepithelialized mucoperiosteal flap. The expression of EGFR in both flaps may be attributed to the influences of different connective tissue substrates which induce a control mechanism to maintain the equilibrium between differentiation and proliferation of epithelium. 1998-06 110002985066 AA11097826 ENG NII-ELS IR 3 Immunohistochemical Study on Epithelialization of the Fascial Flap in the Oral Cavity of Rats Nagata Natsuki Inokuchi Tsugio Ikeda Hisazumi Elshal Elsherbini Elazazy Japanese Society for Oral Pathology Oral medicine & pathology The immunohistochemical expressions of epidermal growth factor receptor (EGFR) and Proliferating Cell Nuclear Antigen (PCNA) were studied in the epithelialization process of bare flaps, the fascial flap and the deepithelialized mucoperiosteal flap, used for reconstruction of the oral mucosa in rat models. The intense expression of EGFR and PCNA was detected in the tip area of the migrating epithelium during the early period of the healing process in both flaps, and differing distributions of EGFR and PCNA positive cells were identified. In the fascial flap, a significantly high positive rate of EGFR was detected in comparison with the deepithelialized mucoperiosteal flap. The expression of EGFR in both flaps may be attributed to the influences of different connective tissue substrates which induce a control mechanism to maintain the equilibrium between differentiation and proliferation of epithelium. Nagata Natsuki Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry Inokuchi Tsugio Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry Ikeda Hisazumi Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry Elshal Elsherbini Elazazy Former guest research fellow, Nagasaki University