各種動物における N-アセチルグルコサミン-6-燐酸デアセチラーゼの密度分布

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タイトル別名
  • A STUDY ON THE DISTRIBUTION OF N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE IN ANIMAL ORGANS
  • カクシュ ドウブツ ニ オケル N-アセチルグルコサミン 6 リンサン デアセチラーゼ ノ ミツド ブンプ

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Distribution of N-acetylglucosamine-6-phosphate deacetylase in the organs of a variety of mammals and aquatic organisms was studied. The mammals used in this study included monkey, cattle, hog, dog, rabbit, rat, mouse, guinea pig and some samples from human origin. The aquatic amimals studied included a variety of common edible fishes together with a few species of amphibia, mollusca and crustaceae. Although organs from such lower animals were studied for their contents of the enzyme, data obtained were not conclusive and could serve only for qualitative comparison with those obtained from mammalian organs which comprised mainly parotid and submaxillary glands, heart, lung, liver, stomach, spleen, kidney, small and large intestine and sometimes muscle. In the study of organ distribution, it was most significant that kidney and spleen proved richest in this enzyme through all animal species studied with its density amounting to 2 to 5 times those of other organs. The higher level of this enzyme in the spleen may be suggestive of its association with the physiological function that involves destruction of erythrocytes in the blood stream, especially of their cell wall which is made of protein and lipid complexes of aminopolysaccharides. The aminosugars released from hydrolyzates of the cell wall may undergo deacetylation in this organ. The equally high level of the enzyme in the kidney could not readily be explained on any physiological basis at this time. However, studies are available which reported the highest content of bound hexosamines in the kidney as compared with other organs. If this is the case, the kidney requires general abundance of enzymes concerned with the metabolism of aminosugars and hence the richness of the present enzyme that deacetylates phosphate esters of acetylhexosamines. Studies in rats with regard to possible sex difference in the enzyme distribution tended to show that the enzyme was distributed more richly in the male than in the female. Age difference studies were conducted with use of grouped mice aged 5 to 15 months and results showed that the enzyme concentration increased progressively with age. Studies on the effects of subcutaneous administration of N-acetylglucosamine to rats revealed that increased density of the enzyme was observed in spleen, kidney and especially in intestinal canal as compared with those of control animals. Studies on rabbits that were transplanted with the malignant cells of VX_2 Carcinoma's homogenate in the femur muscle showed that the enzyme concentrations in spleen and kidney tended to show a slight decrease and approximately 5 times increase in the central region of tumor as compared with control organs and tissues. Aquatic animals and organisms were shown to share about as much amounts of this enzyme distributed throughout respective organ studied as mammalian animals.

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