静脈麻酔剤メトヘキシタール・ナトリウムの麻酔作用ならびに呼吸血圧作用

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  • Observation of the Effect of Methohexital-Na (Brevital^[○!R] Sodium), an Intravenous Anesthetic, on the Central Nervous, the Respiration and the Cardiovascular System
  • ジョウミャク マスイザイ メトヘキシタール ナトリウム ノ マスイ サヨウ ナ

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Examinations of the effect of Methohexital-Na were made in rabbits and its anesthetic action was observed by Girndt-Magnus's method. The action on the respiration and blood pressure were recorded by a tambour and a mercury manometer. The results were as follows. 1. Methohexital-Na did not cause narcosis in the dose of 1 mg/kg, but in the dose of 5 mg/kg deep anesthesia was obtained. The duration of anesthesia lasted only 2 to 3 minutes. After 6 to 8 minutes, the animal recovered consciousness. 2. In the dose of 5 mg/kg, the respiration and blood pressure were arrested sufficiently. But these depressions soon passed away. After 4 to 5 minutes, the animal recovered consciousness. 3. Narcotic effect of Methohexital-Na was influenced to some extent by its injection speed. When injection was given speedily, narcosis became deeper and depressions increased. But there was no distinct difference whether the injection speed was in 10 or in 60 seconds. Even injection in 10 seconds brought about above mentioned symptoms but it lasted only 10 to 20 seconds. In view of the foregoings, it is considered that Methohexital-Na is an adequate anesthetic without any apparent side-effect in narcotic dose (5 mg/kg) injected in the speed of about 30 seconds.

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