A STUDY OF INHIBITORY EFFECT OF CHONDROITIN POLYSULFATE ON STONE FORMATION OF CALCIUM OXALATE
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- Fujisawa Makoto
- Department of Urology, Asahikawa Medical College
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- Arima Shigeru
- Department of Urology, Asahikawa Medical College
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- Yachiku Sunao
- Department of Urology, Asahikawa Medical College
Bibliographic Information
- Other Title
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- コンドロイチンポリ硫酸の蓚酸カルシウム結石形成に対する抑制作用の検討
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Abstract
Chondroitin polysulfate (CPS) have inhibitory activity on stone formation of calcium oxalate. This study compared the inhibitory effect of three CPS (CPS S-I, CPS S-II, CPS S-III) with sodium pentosan polysulfate (SPP) and chondroitin sulfate (CS). Crystal growth inhibition was measured in a seeded crystal growth system with 14C-oxalate, and CPS S-I and CPS S-II were the most active substances inhibiting crystal growth.<br>Since CPS S-II and CPS S-III had remarkable hemorrhagic adverse effect, these two substances were excluded from the following study. The study of administration of the rest of the substances (CPS S-I, SPP, CS) to rats revealed that CPS S-I highly inhibited formation of stone in kidney. About 65 percent of CPS S-I administered subcutaneously was excreted in 24 hours urine.<br>Therefore it may be of value to study clinical usefulness of CPS S-I for treatment of patient with urolithiasis.
Journal
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- The Japanese Journal of Urology
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The Japanese Journal of Urology 83 (10), 1647-1654, 1992
THE JAPANESE UROLOGICAL ASSOCIATION
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Details 詳細情報について
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- CRID
- 1390001205056258176
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- NII Article ID
- 110003059756
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- NII Book ID
- AN00196577
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- ISSN
- 18847110
- 00215287
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- PubMed
- 1434267
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed