LOW DOSE CVD CHEMOTHERAPY AS A TUMOR DORMANCY THERAPY FOR EXTRA-ADRENAL MALIGNANT PHEOCHROMOCYTOMA

• Maezawa Takuya

  Department of Urology, Cancer Institute Hospital

• Yonese Jyunji

  Department of Urology, Cancer Institute Hospital

• Tsukamoto Tetsurou

  Department of Urology, Cancer Institute Hospital

• Isii Nobuyuki

  Department of Urology, Cancer Institute Hospital

• Hasegawa Yuichi

  Department of Urology, Cancer Institute Hospital

• Fukui Iwao

  Department of Urology, Cancer Institute Hospital

• Ishikawa Yuichi

  Department of Pathology, Cancer Institute

Bibliographic Information

Other Title

• 低用量CVD化学療法が tumor dormancy therapy として有効であった副腎外悪性褐色細胞腫の1例
• A CASE REPORT

Abstract

A 38 year-old man presented with upper abdominal mass and hypertension pointed out at a medical examination. Blood pressure was 170/90 under medication of an α-bloker. Abdominal CT scan showed an 8×8cm inter-aortocaval mass displacing pancreas head ventrally, and further a 4×4cm mass at the aortic bifurcation, but there was no tumorous lesion in bilateral adrenal glands. Plasma nor-epinephrine level and urinary VMA excretion were excessive but plasma adrenaline level was within normal limits. MIBG scintigram showed hot spots in the 4^th and 9^th thoracic vertebrae. The destructive change of the 9^th vertebra on magnetic resonance imaging strongly suggested metastasis of the tumor. Histologic and immunohistochemical findings of the biopsy specimen taken from the lower abdominal tumor in addition to the above clinical data led to the diagnosis of extra-adrenal malignant pheochromocytoma with spinal metastases. Since 2 cycles of full dose CYVADIC chemotherapy had no effects on lowering the high blood pressure and reducing the tumor size, low dose (60% of the full dose) CVD (cyclophosphamide, vincristine and dacarbazine) was given as a palliative chemotherapy on an ont-patient clinic approximately every 4 weeks. After 4 cycles of the chemotherapy, his backache due to spinal metastasis markedly improved, hypertension as well as the plasma dopamine level was normalized and nor-epinephrine level was markedly decreased, though the tumor size was not reduced. Thereafter, no medication for hypertension was necessary. During 3 years and 6 months until now, 36 cycles of the chemotherapy has been repeated with no significant side effects. He has been at fulltime work with quality of life being well preserved. Low dose CVD regimen appears to be an effective tumor dormancy therapy for advanced extra-adrenal pheochromocytoma.

Journal

• The Japanese Journal of Urology

  The Japanese Journal of Urology 92 (5), 593-596, 2001

  THE JAPANESE UROLOGICAL ASSOCIATION

Keywords

• malignant pheochromocytoma
• CVD chemotherapy
• tumor dormancy therapy

Details

• CRID: 1390282680034098304
• NII Article ID: 110003089253
• NII Book ID: AN00196577
• DOI: 10.5980/jpnjurol1989.92.593
• ISSN: 18847110
• ISSN: 00215287
• PubMed: 11517573
• Web Site: https://search.jamas.or.jp/link/ui/2002052427
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed