A MALE CASE OF PRIMARY BILATERAL BREAST CANCERS DURING ESTROGEN THERAPY FOR PROSTATE CANCER

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  • 前立腺癌に対するエストロゲン療法中に発生した両側性乳癌の1例

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Abstract

An 82-year old man received total androgen blockade therapy (bilateral orchiectomy and 375mg/day flutamide) for the treatment of stage C prostate cancer. Serum PSA levels were undetectable for 13months and thereafter increased gradually. We administered estramustine phosphate sodium (EPS) instead of flutamide under the diagnosis of hormone refractory prostate cancer. EPS therepy was discontinued after 9months because serum PSA levels increased again. Then, the patient complained of bilateral breast nodules and pain. Bilateral mammectomies were performed due to bilateral breast cancers which had been diagnosed by aspiration biopsies and radiographic examinations, but he died four months after the operations. Final pathological diagnosis was ductal adenocarcinoma of the breasts. Immunohistochemical study revealed expressions of PSA in the breast cancers. We diagnosed double cancers of the prostate and the breast because of the different expression patterns of progesterone receptor between them. We review the literatures and discuss the diferential diagnosis of prostate cancer and PSA-producing breast cancer.

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