Numerical investigation on nonlinear response of free microbubble illuminated with ultrasound pulse.

  • Soetanto Kawan
    Toth Human Science and Technology Center (HUSTEC), Department of Control and System Engineering, Faculty of Engineering, Toth University
  • Takeuchi Shinichi
    Toth Human Science and Technology Center (HUSTEC), Department of Control and System Engineering, Faculty of Engineering, Toth University
  • Okujima Motoyoshi
    Toth Human Science and Technology Center (HUSTEC), Department of Control and System Engineering, Faculty of Engineering, Toth University

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  • Numerical investigation on nonlinear re

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Recently, new ultrasound imaging methods and new blood flow-metry using higher harmonics components based on nonlinear behavior of microbubble ultrasound contrast agent are studied. These ultrasound diagnostic equipment using with ultrasound contrastagentscan be used to improve the accuracy of blood flow diagnosis and to enhance the image ofabnormal tissue like tumors in the ultrasound diagnostic image. In this paper, the resultsof numerical study on relationship between the ultrasound illuminating condition and higherharmonics components included in scattered wave from free air microbubbles in water isreported to develop such a medical diagnostic equipment using the nonlinear response ofmicrobubble contrast agent. This study is performed for a microbubble with radiuslargerthan 10 [μm] suitable to the contrast agent in artery and for a microbubble withradiussmaller than 10 [μm] suitable to the contrast agent in vein. The nonlinear response of freemicrobubbles with size distribution is also studied concerning with the random spacedistribution.

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