書誌事項
- タイトル別名
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- Usefulness of Type I Collagen N-Terminal Telopeptide (NTx) in the Diagnosis of Bone Metastasis from Lung Cancer.
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抄録
Objective Although bone metastasis from lung cancer is generally revealed by bone scintigraphy, this diagnostic method has many shortcomings, such as false positive results, high cost, limited availability to certain institutes, flare phenomenon, and difficulty in evaluating therapeutic responses of bone metastatic lesions. In recent years, development of new bone metabolic markers has dramatically advanced. In the present study, we evaluated the usefulness of Type I collagen N-terminal telopeptide (NTx), a metabolite of type I collagen, for the diagnosis of bone metastasis from lung cancer.<BR>Methods and Results: The mean urinary NTx level was 112.7±83.9 nM BCE/mM Cr in lung cancer patients with bone metastasis, whereas lung cancer patients without bone metastasis had a significantly lower level (p<0.001). In patients who could be followed up, the urinary NTx levels significantly increased as bone metastasis progressed (p=0.008). The NTx levels at the time of detection of bone metastasis during follow up were significantly higher than those observed at initial examination (p=0.028).<BR>Conclusions: NTx is useful for auxiliary diagnosis of bone metastasis, and can quantify bone metastasis with some accuracy. This marker is also thought to be an auxiliary parameter for the evaluation of progression of bone metastasis.
収録刊行物
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- 肺癌
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肺癌 40 (3), 179-184, 2000
特定非営利活動法人 日本肺癌学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204679369728
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- NII論文ID
- 130003754600
- 110003111495
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- NII書誌ID
- AN00203978
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- ISSN
- 13489992
- 03869628
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
