肺性肥大性骨関節症を伴い,一部に神経内分泌細胞への分化を示した肺癌の1手術例

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  • A Surgical Case of Bronchogenic Carcinoma Partially Showing Neuroendocrine Differentiation, Associated with Pulmonary Hypertrophic Osteoarthropathy.

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Background: Pulmonary hypertrophic osteoarthropathy (PHO) is often associated with bronchogenic carcinoma, but the etiology of PHO is still unknown.<BR>Case: A 61-year-old man was admitted with an abnormal shadow on chest X-ray film. He had clubbed fingers and gonalgia. A diagnosis of bronchogenic carcinoma, associated with pulmonary hypertrophic osteoarthropathy (PHO) was made and right middle-lower lobectomy was performed in August, 1998. After the operation, gonalgia improved, but finger clubbing remained. The histological diagnosis was poorly differentiated squamous cell carcinoma with no evidence of lymph node metastasis, and immunohistochemically some tumor cells were positive for chromogranin A, synaptophysin and gastrin-releasing peptide (GRP).<BR>Conclusion: Hormone assay could not determine the mechanism of occurrence of PHO in this case.

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  • 肺癌

    肺癌 40 (4), 315-320, 2000

    特定非営利活動法人 日本肺癌学会

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