Immunohistochemical Study of Thyroid Transcription Factor-1 Expression in Lung Cancers.

• Ishiwa Naoki

  Division of Anatomic and Surgical Pathology, Yokohama City University Hospital First Department of Surgery, Yokohama City University

• Nakatani Yukio

  Division of Anatomic and Surgical Pathology, Yokohama City University Hospital

• Inayama Yoshiaki

  Division of Anatomic and Surgical Pathology, Yokohama City University Hospital

• Watanabe Katsuya

  First Department of Surgery, Yokohama City University

• Maehara Takamitsu

  First Department of Surgery, Yokohama City University

• Hayashi Yasufumi

  First Department of Surgery, Yokohama City University

• Takanashi Yoshinori

  First Department of Surgery, Yokohama City University

Bibliographic Information

Other Title

• 原発性肺癌におけるＴｈｙｒｏｉｄ　Ｔｒａｎｓｃｒｉｐｔｉｏｎ　Ｆａｃｔｏｒ‐１（ＴＴＦ‐１）発現の免疫組織化学的検討

Abstract

Objective: Recent studies have indicated that the expression of thyroid transcription factor-1 (TTF -1) may be a usefulmarker for lung cancer. In this study we investigated the expression of TTF-1 in lung cancers of various histologicaltypes, and also evaluated the utility of TTF-1 in discriminating between pulmonary and extrapulmonary adenocarcinomas.<BR>Methods: We immunostained 140 carcinomas of pulmonary origin (60 adenocarcinomas (Ads), 30 small cell carcinomas (SCLCs), 40 squamous cell carcinomas (SCCs), 10 large cell carcinomas (LCs)), and 120 adenocarcinomas of extrapulmonaryorigin, using a monoclonal anti-TTF-1 antibody and Catalyzed Signal Amplification (CSA) system on paraffinsections.<BR>Results: In the normal lung, TTF-1 expression was restricted to the nuclei of type II alveolar epithelial cells, Clara cellsand some basal cells of the bronchioles. In lung cancers, TTF-1 expression was detected in 50 cases (83%) of 60 Ads, 20cases (67%) of 30 SCLCs, 3 cases (8%) of 40 SCCs, and 2 cases (20%) of 10 LCs. The frequency of TTF-1 expressionin pulmonary adenocarcinomas showed a positive correlation with degrees of histological differentiation. TTF-1 expressionwas found in 28 cases of 30 thyroid cancers, but otherwise in only one case of 90 extrapulmonary adenocarcinomas.<BR>Conclusion: The results suggest that TTF-1 can be a very useful marker discriminating adenocarcinomas of pulmonaryorigin from those of other sites, excluding the thyroid.

Journal

• Haigan

  Haigan 41 (1), 45-49, 2001

  The Japan Lung Cancer Society

Keywords

• Thyroid transcription factor-1
• Lung cancer
• Extrapulmonary adenocarcinoma
• Immunohistochemistry

Details

• CRID: 1390001204677743104
• NII Article ID: 130003920355
• NII Article ID: 110003117100
• NII Book ID: AN00203978
• DOI: 10.2482/haigan.41.45
• ISSN: 13489992
• ISSN: 03869628
• ISSN: http://id.crossref.org/issn/03869628
• Web Site: http://www.jstage.jst.go.jp/article/haigan1960/41/1/41_1_45/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001183727
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed