悪性胸膜中皮腫９例の胸腔鏡所見，組織学的所見と臨床所見の関連についての検討

DOI Web Site 被引用文献12件 参考文献21件

書誌事項

タイトル別名
  • Thoracoscopic Appearance and Histological Findings of Nine Cases of Pleural Malignant Mesothelioma in Relation to Clinical Findings.

この論文をさがす

抄録

We examined the thoracoscopic appearance and histological finding of nine cases of malignant pleural mesothelioma and classified them into two types: multiple nodular type (5 cases) and non-specific pleural thickening type (4 cases). We determined the relationship between these types and the clinical findings to evaluate the significance of this classification. The mean age of the patients was 66. Seven cases were epithelial type and the rest were biphasic type. Pleural biopsy under thoracoscopic guidance led to a diagnosis in six of nine cases (67%). Histologically, in multiple nodular type disease, the parietal pleura was covered with multiple small, flat nodules and tumor cells were spread on the mesothelial surface. In non-specific pleural thickening type cases, the parietal pleura was thickened, and small nodules were rare. Histologically, tumor cells were not detected (2 cases) or were confined to the submesothelial tissue (2 cases). We speculate that this thoracoscopic appearance is caused by the submesothelial spread of tumor cells. In nodular type cases, serum inflammatory reaction was rare, while in the pleural thickening type, it was frequent. Hyaluronic acid in the pleural effusion was significantly elevated in the nodular type (814±259 vs 36±8μg/ml [mean±SEM], p=0.01, Mann-Whitney U-test). We conclude that this classification is useful for evaluating clinical findings in cases of pleural malignant mesothelioma.

収録刊行物

  • 肺癌

    肺癌 37 (3), 335-345, 1997

    特定非営利活動法人 日本肺癌学会

被引用文献 (12)*注記

もっと見る

参考文献 (21)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ