肉腫像を伴う末梢型肺腺癌，Ｐｌｅｏｍｏｒｐｈｉｃ　Ｃａｒｃｉｎｏｍａ（ＷＨＯ）の１例　　Ｋｉ‐６７による増殖能の検討

• 南 健一郎

  関西医科大学胸部心臓血管外科

• 齊籐 幸人

  関西医科大学胸部心臓血管外科

• 大宮 英泰

  関西医科大学胸部心臓血管外科

• 今村 洋二

  関西医科大学胸部心臓血管外科

• 坂井田 紀子

  関西医科大学臨床検査医学科

• 岡村 明治

  国際診断病理センター

書誌事項

タイトル別名

• A Case of Pulmonary Adenocarcinoma Accompanied by Sarcomatous Findings(Pleomorphic Carcinoma, WHO), With Special Reference to the Growth Potentiality.
• Reference to the Growth Potentiality
• Ki-67による増殖能の検討

抄録

Backgroud. The biological characteristics of pulmonary carcinoma with sarcomatoid elements are not well known. We report an uncommon case of adenocarcinoma with sarcomatoid findings (classification of the Japan Lung Cancer Society-JLCS) or pleomorphic carcinoma (WHO), with special reference to biological characteristics evaluated by the immunohistochemistry using cytokeratin, epithelial membrane antigen, vimentin and Ki-67 (MIB-1). Case. A 75-year-old man consulted us about an abnormal shadow near the right hilum on chest X-ray. Brushing cytology showed adenocarcinoma cells of the lung. Bilobectomy was performed, because the tumor (25× 22mm) was located in peripheral S⁵ and invaded directly into the upper lobe. The TNM staging of the tumor was pT2N0M0, stage IB. Histopathologically, the main components of the tumor appeared to be sarcomatoid spindle cells (positive for cytokeratin) with mild lymphocytic infiltrates. In any other part, foci of conventional moderately differentiated adenocarcinoma were identified. Additionally, foci of adenocarcinoma and sarcomatoid components were intermingled with each other. Thistumor was diagnosed as adenocarcinoma with sarcomatous findings (JLCS) or pleomorphic carcinoma (WHO). Immunohistochemically, cytokeratin was positive in both components, EMA (epithelial membrane antigen) in adenocarcinoma component, and peculiarly Ki-67 labelled cells in the sarcomatoid component were more numerous than those in the adenocarcinoma. Conclusions. 1. An operated case of pleomorphic carcinoma was reported. 2. Immunohistologically, Ki-67 labelled cells in sarcomatoid components were distinctly more numerous than those in adenocarcinoma. 3. We conclude that the tumor cells located in the sarcomatoid components are cells transforming into more poorly differentiated and highly proliferative cells than those of the adenocarcinoma components.

収録刊行物

• 肺癌

  肺癌 42 (1), 29-33, 2002

  特定非営利活動法人 日本肺癌学会

キーワード

• 形癌
• 腺癌
• 肉腫成分
• 免疫組織化学

詳細情報

• CRID: 1390282679655779968
• NII論文ID: 130003920403
• NII論文ID: 110003127620
• NII書誌ID: AN00203978
• DOI: 10.2482/haigan.42.29
• ISSN: 13489992
• ISSN: 03869628
• ISSN: http://id.crossref.org/issn/03869628
• Web Site: http://www.jstage.jst.go.jp/article/haigan1960/42/1/42_1_29/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2002184687
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可