Nuclear Envelope Breakdown Is a Prominent Feature in Spinal Motor Neurons of Wasted Mice

• Ueda Hideho

  Department of Anatomy and Cell Biology, School of Health Sciences, Shinshu University

• Tezuka Hideo

  Center for Life Science Research, Yamanashi Medical University

• Nakamura Akinori

  3rd Department of Internal Medicine, Shinshu University School of Medicine

抄録

It has been thought that the wasted mouse is a good model for motor neuron disease. Recently, it was found that the wasted mouse is caused by a gene defect of elongation factor 1α2, but the mechanism of the abnormal phenotype remains poorly understood. In the present study, we examined spinal motor neurons of wasted mice with light and electron microscopy. Confocal images with lamin B immunolabeling and conventional electron micrographs demonstrate that nuclear envelope breakdown (NEB) is a prominent feature of large motor neurons in wasted mice, although probable intercalated neurons or glial cells show no abnormalities. Furthermore, motor neuron death in wasted mice seems to be neither apoptosis nor necrosis. These data suggest that to understand the mechanism about NEB of the spinal motor neuron in wasted mice could shed light on certain motor neuron diseases.<br>

収録刊行物

• Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ

  Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ 37 (3), 159-162, 2004

  日本組織細胞化学会

キーワード

• wasted mice
• spinal cord
• motor neuron
• nuclear envelope breakdown (NEB)
• motor neuron disease

詳細情報

• CRID: 1390282679839809024
• NII論文ID: 110003144377
• NII書誌ID: AA00508022
• DOI: 10.1267/ahc.37.159
• ISSN: 13475800
• ISSN: 00445991
• Web Site: http://www.jstage.jst.go.jp/article/ahc/37/3/37_3_159/_pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10804648
• Web Site: https://search.jamas.or.jp/link/ui/2006021650
• 本文言語コード: en
• データソース種別:
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