Immunohistochemical studies on tumor antigen-4 in squamous cell carcinoma of uterine cervix.
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- MATSUTA MORIMASA
- Department of Obstetrics and Gynecology, Iwate Medical University, School of Medicine
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- KAGABU TERUO
- Department of Obstetrics and Gynecology, Iwate Medical University, School of Medicine
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- NISHIYA IWAO
- Department of Obstetrics and Gynecology, Iwate Medical University, School of Medicine
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Immunohistochemical localization of Tumor Antigen 4 (TA-4) in squamous cell carcinoma (SCC) tissues of the uterine cervix was studied by means of the immunoperoxidase methods. Light microscopic detection of TA-4 was carried out by means of the avidin-biotin-peroxidase complex method on formalin-fixed paraffin-embedded sections from 92 cases of invasive cervical cancer of the uterus. These tumors were histologically SCC, consisting of 68 of the large cell non-keratinizing (LNK) type and 24 of the keratinizing (K) type. TA-4 positive cells were detected in 65% of LNK cases and 100% of K cases. Positively stained neoplastic cells were seen frequently around the hyperparakeratotic lesions, and they showed a tendency to keratinization.<br>TA-4 localization was also confirmed in the cells of stratum spinosum of the non-cancerous squamous epithelium.<br>Subcellular localization of TA-4 was studied by the preembedding indirect immunoperoxidase method. TA-4 was localized in the cytosols of the neo-plastic cells, but not in tonofilaments. It was suggested that TA-4 was a structural protein of SCC. Therefore, unlike keratin, TA-4 can be considered as an index of differentiation of SCC cells, and TA-4 should be useful as a tumor marker which expresses the characteristics of the neoplastic tissue during squamous maturation.
収録刊行物
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- Acta Histochemica et Cytochemica
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Acta Histochemica et Cytochemica 20 (1), 75-85, 1987
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詳細情報 詳細情報について
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- CRID
- 1390001204860907136
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- NII論文ID
- 110003150036
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- NII書誌ID
- AA00508022
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- COI
- 1:CAS:528:DyaL2sXktlOltLk%3D
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- ISSN
- 13475800
- 00445991
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可