Foot Hyperalgesia after Thoracic Burn Injury. Histochemical, Behavioral and Pharmacological Studies.

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  • Ueda Masashi
    Department of Anesthesiology, Kyoto Prefectural University of Medicine
  • Hirose Munetaka
    Department of Anesthesiology, Kyoto Prefectural University of Medicine
  • Takei Nobuyuki
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University
  • Ibuki Takae
    Department of Anesthesiology, Kyoto Prefectural University of Medicine
  • Naruse Yoshihisa
    Department of Anatomy & Neurobiology, Kyoto Prefectural University of Medicine
  • Ibata Yasuhiko
    Office of the President, Kyoto Prefectural University of Medicine
  • Tanaka Masaki
    Department of Anatomy & Neurobiology, Kyoto Prefectural University of Medicine

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  • -Histochemical, Behavioral and Pharmacological Studies-

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Using behavioral, immunohistochemical and pharmacological studies, we report here that large thoracic burn injuries remotely induce hindpaw hyperalgesia during the healing stage.<br> During 2-3 weeks after thoracic burn injury when the skin was regenerating from the wound, we observed by formalin test that the number of flinching behaviors significantly increased and simultaneously we observed by von Frey test that rats developed mechano-hyperalgesia in the foot. In the dorsal horn of the lumbar spinal cord in burn injured rats, c-Fos expression was significantly augmented after plantar formalin injection. The expression of μ-opioid receptor in burn injured rats was significantly decreased compared with that in sham operated rats. The expression of substance P and CGRP in the lumbar dorsal horn was not different between burn and sham operated animals. We also observed that intrathecal administration of glutamate receptor antagonists (MK801 and CNQX) but not cyclooxigenase-2 antagonist (NS-398) reversed the threshold of von Frey test on the foot up to the control level at 2 weeks after injury.<br> Collectively, we analyzed a new pain model showing foot hyperalgesia after thoracic burn injury and demonstrated that neurotransmission of glutamate was enhanced at the lumbar spinal cord level by immunocytochemistry and intrathecal administration of NMDA and non NMDA antagonists.<br> Although the precise mechanism of how remote hyperalgesia at the healing stage developed in this model remains to be confirmed, substances such as trophic factors released from the regenerating skin may cause systemic hyperalgesia including in the foot.<br>

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