置換液の安全性(<特集>アフェレシスにおけるセイフティーマネジメント)  [in Japanese] Safety of Displacement Liquid for Plasma Exchange Therapy  [in Japanese]

Fresh frozen plasma (FFP) is used as displacement liquid for plasma exchange therapy in the cases requiring some coagulation factors and other plasma factors, whereas albumin products should be selected in the cases requiring only to maintain the colloid osmotic pressure of blood. Although FFP may be considered to be safe as to transfusion-transmitted disease, immunological adverse events such as transfusion-related lung injury (TRALI) or alloimmunization should be kept in mind. Albumin products are safer than FFP because they are treated with various pathogen inactivation procedures and have few alloantigens. Therefore, albumin products should be used for displacement liquid in plasma exchange therapy as far as possible.