フノリ抽出物と第２リン酸カルシウムを配合したキシリトールチューインガムの実験的初期う蝕エナメル質に及ぼす再石灰化促進効果

• 佐伯 洋二

  (株) ロッテ中央研究所基礎研究部素材開発研究室

• 高橋 満

  (株) ロッテ中央研究所基礎研究部素材開発研究室

• 上川 新吾

  (株) ロッテ中央研究所開発研究部チューインガム研究室

• 徳本 匠

  (株) ロッテ中央研究所開発研究部チューインガム研究室

• 見明 康雄

  東京歯科大学 口腔科学研究センター

• 山田 了

  東京歯科大学 口腔科学研究センター

• 奥田 克爾

  東京歯科大学 口腔科学研究センター

• 柳澤 孝彰

  東京歯科大学 口腔科学研究センター

書誌事項

タイトル別名

• Remineralization Effect of Xylitol Chewing Gum Containing Gloiopeltis furcata Extract and Calcium Hydrogenphosphate on Initial Caries-like Enamel Lesions.

抄録

The objective of the present study was to investigate the beneficial effects of xylitol chewing gum containing Gloiopeltis furcata extract and calcium hydrogenphosphate on remineralization of initial carieslike enamel lesions. Initial caries-like enamel lesions were artificially prepared by demineralizing human enamel blocks with a 0.01M acetate buffer (pH 4.0) at 50°C. We investigated sucrose gum (control), xylitol gum, and xylitol gum containing G. furcata extract and calcium hydrogenphosphate. In the in vitro intvestigation, the enamel blocks having initial caries-like enamel lesions were immersed in a remineralizing solution containing the extract of each chewing gum at 37°C for 2 weeks, and then evaluated for degrees of remineralization by contact microradiography. The remineralizing potential of each chewing gum in vivo was also evaluated by an oral device fixed with artificially demineralized human enamel block. Each subject was fixed on this device on the lingual surface of the mandibular molar for one week, and was given chewing gum samples 7 times a day. This in vivo study was carried out by the double-blind method.<BR>It was found that xylitol gum enhanced the remineralization of initial caries-like enamel lesions, and that xylitol gum containing G. furcata extract and calcium hydrogenphosphate promoted the action of xylitol gum on remineralization. These findings suggest that adding G. furcata extract and calcium hydrogenphosphate to xylitol gum can amplify the remineralization effect of xylitol and can be expected to be effective in reducing dental caries.

収録刊行物

• 歯科基礎医学会雑誌

  歯科基礎医学会雑誌 42 (6), 590-600, 2000

  歯科基礎医学会

キーワード

• xylitol
• remineralization
• Gloiopeltis furcata extract
• calcium hydrogenphosphate
• enamel

詳細情報

• CRID: 1390001204682742656
• NII論文ID: 130004001973
• NII論文ID: 110003166759
• NII書誌ID: AN00100090
• DOI: 10.2330/joralbiosci1965.42.590
• ISSN: 03850137
• ISSN: http://id.crossref.org/issn/03660567
• Web Site: https://search.jamas.or.jp/link/ui/2001167267
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可