Ｓｔｒｅｐｔｏｃｏｃｕｓ　ｓｏｂｒｉｎｕｓ６７１５株接種ラットにおける塩化デカリニウムおよび臭化ドミフェンのう蝕抑制効果

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  • Inhibitory Effects of Dequalinium Chloride and Domiphen Bromide on Caries Development in Rats Inoculated with Streptococcus sobrinus 6715.

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The effects of dequalinium chloride (DC) and domiphen bromide (DB), which have an inhibitory action on water-insoluble glucan synthesis and an antibacterial action, on caries development were examined in male SD rats (ca. 50g) orally inoculated with S. sobrinus 6715. 0.02% DC solution, 0.02% DB solution or tap water (control) was administered ad libitum to the rats as drinking water for 54 days. The number of S. sobrinus cells adhering to molar surfaces was markedly less in the 0.02% DC and 0.02% DB groups than in the control group in the middle and latter test periods. The caries scores of smooth surface and sulcal lesions were lower in the 0.02% DC and 0.02% DB groups than in the control group, whereas those of proximal lesions were as follows, in decreasing order: 0.02% DB group>control group>0.02% DC group. When evaluated by the sum of the caries scores of the three lesions, the 0.02% DC- and 0.02% DB-induced suppression of caries development was 68% and 34%, respectively. There was no toxic effect of DC or DB on rats under the present experimental conditions. From these results, it can be considered that DC and DB inhibited caries development by decreasing the number of bacterial cells adhering to the teeth.

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