実験的脊髄損傷におけるedaravoneの有用性の検討

• 籬 拓郎

  広島大学大学院医歯薬学総合研究科脳神経外科

• 栗〓 薫

  広島大学大学院医歯薬学総合研究科脳神経外科

• 山口 智

  広島大学大学院医歯薬学総合研究科脳神経外科

• 岡崎 貴仁

  広島大学大学院医歯薬学総合研究科脳神経外科

• 武田 正明

  広島大学大学院医歯薬学総合研究科脳神経外科

書誌事項

タイトル別名

• Effect of Free Radical Scavenger Edaravone on Experimental Spinal Cord Injury
• - Functional Recovery and Axonal Protection -
• ―運動機能回復と軸索保護作用について―

抄録

Generation of free radical plays an important role in development of secondary spinal cord injury (SCI). Edaravone is a free radical scavenger, and has been used for protection against ischemia in patients with cerebral infarction. We investigated the effect of edaravone on severe experimental SCI. Treatment with edaravone (3mg/kg of body weight administered intravenously and subcutaneously (s.c.) immediately after injury, plus 3mg/kg s.c. on day 1 and day 2) was compared with saline treatment in rats subjected to severe 50 g · cm weight drop thoracic SCI. Neurological recovery was evaluated periodically over 3 weeks by BBB locomotor rating scale and inclined plane method (IPM). To investigate protective effect of edaravone on axons, we evaluated the preservation of rubrospinal tract by counting red nucleus (RN) cells labeled retrogradely from lumbar spinal cord with fluorescent tracer. Edaravone significantly improved recovery in early phase in both BBB scale and IPM. The number of labeled RN neurons of edaravone-treated group had a tendency to be larger than of control group. These results indicate that edaravone has therapeutic potential for protecting the injured spinal cord.

収録刊行物

• 脊髄外科

  脊髄外科 19 (4), 315-320, 2005

  日本脊髄外科学会

キーワード

• spinal cord injury
• edaravone
• free radical
• secondary injury
• axonal preservation

詳細情報

• CRID: 1390001205228888576
• NII論文ID: 110003488722
• NII書誌ID: AN10283463
• DOI: 10.2531/spinalsurg.19.315
• ISSN: 18809359
• ISSN: 09146024
• Web Site: https://search.jamas.or.jp/link/ui/2006319704
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可