Inhibitory Effect of Stevioside on Tumor Promotion by 12-O-Tetradecanoylphorbol-13-acetate in Two-Stage Carcinogenesis in Mouse Skin.

• Yasukawa Ken

  College of Pharmacy, Nihon University

• Kitanaka Susumu

  College of Pharmacy, Nihon University

• Seo Shujiro

  Tokiwa Phytochemical Co., Ltd.

抄録

Four steviol (ent-kaurene-type diterpenoid) glycosides, stevioside, rebaudiosides A and C, and dulcoside A, have been isolated from Stevia rebaudiana BERTONI. These compounds showed strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 54.1—291.6 μg/ear. Furthermore, at 1.0 and 0.1 mg/mouse of stevioside mixture, the mixture of these compounds markedly inhibited the promoting effect of TPA (1 μg/mouse) on skin tumor formation initiated with 7,12-dimethylbenz[a]anthracene (50 μg/mouse).

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 25 (11), 1488-1490, 2002

  公益社団法人 日本薬学会

キーワード

• stevioside
• antitumor promoter
• stevia
• two-stage carcinogenesis
• 12-<i>O</i>-tetradecanoylphorbol-13-acetate
• <i>ent</i>-kaurene-type diterpene glycosides

詳細情報

• CRID: 1390001204626259840
• NII論文ID: 110003608272
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.25.1488
• COI: 1:CAS:528:DC%2BD38XptlGks78%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 6342851
• PubMed: 12419967
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6342851
• Web Site: http://www.jstage.jst.go.jp/article/bpb/25/11/25_11_1488/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003105445
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可