Effects of Sesamin on Aortic Oxidative Stress and Endothelial Dysfunction in Deoxycorticosterone Acetate-Salt Hypertensive Rats
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- Nakano Daisuke
- Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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- Itoh Chie
- Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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- Ishii Fumie
- Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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- Kawanishi Hideaki
- Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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- Takaoka Masanori
- Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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- Kiso Yoshinobu
- Institute for Health Care Science, Suntory Ltd.
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- Tsuruoka Nobuo
- Institute for Health Care Science, Suntory Ltd.
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- Tanaka Takaharu
- Institute for Health Care Science, Suntory Ltd.
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- Matsumura Yasuo
- Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Abstract
In the present study, we evaluated the relationship between the antihypertensive effect of sesamin, a lignan from sesame oil, and its antioxidative activity in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. After a 5-week treatment period, systolic blood pressure was significantly elevated in normal diet-fed DOCA-salt animals compared with cases in sham-operated animals. Sesamin feeding, tempol (a superoxide dismutase mimetic) treatment or antihypertensive drugs combination (triple therapy; reserpine, hydralazine, hydrochlorothiazide) significantly suppressed the development of DOCA-salt-induced hypertension. Compared with sham-operated rats, the normal diet-fed DOCA-salt rats revealed marked increases in aortic superoxide (O2−) production. These increases in O2− production were significantly suppressed by sesamin feeding or tempol treatment, but not by triple therapy. Acetylcholine (Ach)-induced endothelium-dependent relaxation was markedly decreased in normal diet-fed DOCA-salt rats, compared with cases in sham-operated rats. Sesamin feeding and triple therapy significantly improved the DOCA-salt-induced impairment of endothelium-dependent relaxation. However, tempol treatment had no effect on the impaired vasodilator responses induced by DOCA-salt treatment. In DOCA-salt rats with or without sesamin feeding, systolic blood pressure significantly correlated with both aortic O2− production and endothelium-dependent vascular relaxation. These findings suggest that sesamin feeding inhibits the enhancement of aortic O2− production in DOCA-salt hypertensive rats, and this effect may contribute to the antihypertensive effect of sesamin. Sesamin feeding-induced improvement of endothelial dysfunction seems to result from the above antioxidative and antihypertensive effects.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 26 (12), 1701-1705, 2003
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679602806272
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- NII Article ID
- 110003608376
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- NII Book ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD3sXpvFaksrc%3D
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 6766799
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- PubMed
- 14646174
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed