Ichthyotoxic and Anticarcinogenic Effects of Triterpenoids from Sandoricum koetjape Bark
-
- Ismail Intan Safinar
- Faculty of Pharmaceutical Sciences, Okayama University
-
- Ito Hideyuki
- Faculty of Pharmaceutical Sciences, Okayama University
-
- Mukainaka Teruo
- Kyoto Prefectural University of Medicine
-
- Higashihara Hiroshi
- Kyoto Prefectural University of Medicine
-
- Enjo Fumio
- Kyoto Prefectural University of Medicine
-
- Tokuda Harukuni
- Kyoto Prefectural University of Medicine
-
- Nishino Hoyoku
- Kyoto Prefectural University of Medicine
-
- Yoshida Takashi
- Faculty of Pharmaceutical Sciences, Okayama University
この論文をさがす
抄録
After bioassay-guided fractionation of the extract from Sandoricum koetjape bark, which exhibited significant toxicity to killifish (Oryzias latipes), two ichthyotoxic triterpenoids were isolated and characterized as koetjapic acid and 3-oxo-olean-12-en-29-oic acid. These constituents, along with non-toxic katonic acid, had a remarkable inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA), which is a preliminary in vitro screening method for possible anti-tumor-promoting agents. Of the triterpenoids active in vitro, koetjapic acid appears to be a promising cancer chemopreventive agent, since it significantly delayed tumor promotion in two-stage mouse skin carcinogenesis induced by 7,12-dimethylbenz(a)anthracene and promoted by TPA.
収録刊行物
-
- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
-
Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 26 (9), 1351-1353, 2003
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679605222528
-
- NII論文ID
- 110003608602
-
- NII書誌ID
- AA10885497
-
- COI
- 1:STN:280:DC%2BD3svhtFalsA%3D%3D
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 6658441
-
- PubMed
- 12951486
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可