Intradermal Concentration of Hydroquinone after Application of Hydroquinone Ointments Is Higher than Its Cytotoxic Concentration
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- Matsubayashi Teruhisa
- Department of Hospital Pharmacy, School of Medicine, Kobe University
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- Sakaeda Toshiyuki
- Department of Hospital Pharmacy, School of Medicine, Kobe University
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- Kita Tomoko
- Department of Hospital Pharmacy, School of Medicine, Kobe University
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- Kurimoto Yoshie
- Department of Hospital Pharmacy, School of Medicine, Kobe University
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- Nakamura Tsutomu
- Department of Hospital Pharmacy, School of Medicine, Kobe University
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- Nishiguchi Kohshi
- Department of Hospital Pharmacy, School of Medicine, Kobe University
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- Fujita Takuya
- Department of Biopharmaceutics, Kyoto Pharmaceutical University
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- Kamiyama Fumio
- Department of Biopharmaceutics, Kyoto Pharmaceutical University
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- Yamamoto Akira
- Department of Biopharmaceutics, Kyoto Pharmaceutical University
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- Okumura Katsuhiko
- Department of Hospital Pharmacy, School of Medicine, Kobe University
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抄録
Ointments of the skin depigmentation agent hydroquinone (HQ) have been prepared by extemporaneous nonsterile compounding in our hospital. The HQ ointments were highly effective in the treatment of various types of skin pigmentations; however, various problems have emerged including chromatic aberration of the ointments, a relatively large variability of efficacy, and mild topical side effects including irritation. In this paper, the cytotoxicity of HQ was assessed in vitro using rat skin fibroblasts as the concentration with 50% survival after 24 h exposure to be 16.5 μM. The intradermal concentrations at 2 h after application of the HQ ointments was also estimated to be 358 mM and 51.7 mM in stratum corneum and viable tissue (viable epidermis+dermis), respectively, by an in vitro rat skin permeation study with rat full-thickness abdominal skin and Franz-type diffusion cells. It was demonstrated that the intradermal concentration of HQ was much higher than that eliciting cytotoxicity, suggesting that the topical side effects after application of HQ ointment were due to the cytotoxicity of HQ.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 26 (9), 1365-1367, 2003
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679605226496
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- NII論文ID
- 110003608606
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BD3svislyisg%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 6658563
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- PubMed
- 12951490
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可