Momordica charantia Extracts Inhibit Uptake of Monosaccharide and Amino Acid across Rat Everted Gut Sacs in-Vitro

• Mahomoodally Mohamad Fawzi

  Department of Health and Medical Sciences, Faculty of Science, University of Mauritius

• Fakim Ameenah-Gurib

  Department of Chemistry, Faculty of Science, University of Mauritius

• Subratty Anwar Hussein

  Department of Health and Medical Sciences, Faculty of Science, University of Mauritius

Abstract

The inhibitory effects of Momordica charantia extracts were studied on the uptake of glucose and tyrosine across rat everted gut sacs in vitro. The aqueous extract of the plant was found to inhibit primarily the uptake of glucose in a dose-dependent manner. Uptake of tyrosine was affected at high substrate concentrations only. The extract was also found to decrease the absorptive capacity of fluid across the small intestine and sodium ions. It is hypothesized that the effects of Momordica could involve a washout of glucose from the blood stream.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 27 (2), 216-218, 2004

  The Pharmaceutical Society of Japan

Keywords

• <i>Momordica charantia</i>
• glucose
• tyrosine
• transport
• diabetes

Details

• CRID: 1390282679601656448
• NII Article ID: 110003608732
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.27.216
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 6826842
• PubMed: 14758036
• Web Site: http://id.ndl.go.jp/bib/6826842
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6826842
• Web Site: http://www.jstage.jst.go.jp/article/bpb/27/2/27_2_216/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2004129619
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed