Suppressive Activity of the Fruit of Momordica charantia with Exercise on Blood Glucose in Type 2 Diabetic Mice

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  • Miura Toshihiro
    Department of Clinical Nutrition, Suzuka University of Medical Science
  • Itoh Yasushi
    Department of Clinical Nutrition, Suzuka University of Medical Science
  • Iwamoto Naoki
    Department of Clinical Nutrition, Suzuka University of Medical Science
  • Kato Motoshi
    Department of Clinical Nutrition, Suzuka University of Medical Science
  • Ishida Torao
    Hi-tech Research Center, Suzuka University of Medical Science

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The antidiabetic activity of Momordica charantia L. (Cucurbitaceae) with exercise was investigated in KK-Ay mice, an animal model with type 2 diabetes with hyperinsulinemia. The water extract of the fruit of Momordica charantia L. (MC) with exercise reduced the blood glucose of KK-Ay mice 5 weeks after oral administration (p<0.001), and also significantly lowered the plasma insulin of KK-Ay mice under similar conditions (p<0.01). The blood glucose of MC with exercise is lower than that of MC only or exercise only 5 weeks after the administration. MC with exercise decreased blood glucose in a glucose tolerance test. These results suggest that MC with exercise is useful for type 2 diabetic cure.

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