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- Mun Yeun-Ja
- Department of Herbal Resources, Wonkwang University
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- Lee Sung-Won
- Department of Herbal Resources, Wonkwang University
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- Jeong Hyun-Woo
- Department of Pathology, College of Oriental Medicine, Dongshin University
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- Lee Kwang-Gyu
- Department of Pathology, College of Oriental Medicine, Woosuk University
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- Kim Joung-Hoon
- Department of Herbal Resources, Wonkwang University
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- Woo Won-Hong
- Department of Herbal Resources, Wonkwang University
書誌事項
- タイトル別名
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- Inhibitory Effect of Miconazole on Melanogenesis
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抄録
Miconazole (MIC), a regional antifungal agent, has been used worldwide in the treatment of superficial mycosis. However, the effect of MIC on skin pigmentation is not known. In this study, we investigated the inhibitory effect of MIC on melanogenesis in B16 melanoma cells. Tyrosinase activity and melanin content were dose dependently decreased by MIC as compared with untreated cells. The level of tyrosinase protein expression was reduced with treatment MIC. A decrease in cell proliferation was observed in B16 cells treated with MIC 30 μM, indicating that the MIC-induced depigmenting effect was caused by inhibition of melanin synthesis and not by destruction of B16 cells. Furthermore, MIC markedly suppressed α-melanocyte stimulating hormone or forskolin-induced tyrosinase activity in B16 cells. Therefore the depigmenting effect of MIC might be due to the inhibition of tyrosinase activity and tyrosinase expression, which eventually slows melanin biosynthesis. These results indicate that MIC may be a useful inhibitor of melanogenesis in B16 cells and suggest that it may have beneficial effects in the treatment of hyperpigmentation disorders such as ephelis and melasma.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 27 (6), 806-809, 2004
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204626351616
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- NII論文ID
- 110003608860
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 6952233
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- PubMed
- 15187422
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可