Passive Cutaneous Anaphylaxis-Inhibitory Action of Tectorigenin, a Metabolite of Tectoridin by Intestinal Microflora
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- Park Eun-Kyung
- Department of Biochemistry, Kon Kuk University
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- Shin Yong-Wook
- College of Pharmacy, Kyung Hee University
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- Lee Hae-Ung
- College of Pharmacy, Kyung Hee University
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- Lee Chang Soo
- Department of Biochemistry, Kon Kuk University
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- Kim Dong-Hyun
- Department of Biochemistry, Kon Kuk University
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抄録
Tectoridin isolated from the flowers of Pueraria thunbergiana (Leguminosae) are metabolized to tectorigenin by human intestinal microflora. When tectoridin was orally administered to rats, tectorigenin, but not tectoridin, was detected in urine after β-glucuronidase hydrolysis. The main metabolite tectorigenin potently inhibited the passive cutaneous anaphylaxis reaction and inhibited in vitro the release of β-hexosaminidase from RBL-2H3 cells induced by IgE. These results suggest that tectoridin is a prodrug, which can be transformed into the active agent tectorigenin by human intestinal bacteria and can be a candidate for antiallergic agent.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 27 (7), 1099-1102, 2004
公益社団法人 日本薬学会
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詳細情報
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- CRID
- 1390282679603878912
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- NII論文ID
- 110003608920
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 6986811
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- PubMed
- 15256747
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可