Protective Effect of Eugenia jambolana Seed Kernel on Tissue Antioxidants in Streptozotocin-Induced Diabetic Rats

• Ravi Kasi

  Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus

• Ramachandran Balasubramanian

  Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus

• Subramanian Sorimuthu

  Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus

Abstract

Oxidative stress plays an important role in chronic complications of diabetes. In the present study the antioxidant effect of oral administration of ethanolic extract of Eugenia jambolana seed kernel on tissue antioxidant enzymes and lipid peroxidation in liver and kidney of streptozotocin-induced diabetic rats was evaluated. Administration of seed kernel to diabetic rats significantly decreased the levels of blood glucose, glycosylated hemoglobin and increased body weight gain, plasma insulin and hemoglobin. The diabetic rats showed the low activities of superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione content in liver and kidney, which were restored to near normal levels by treatment with the seed kernel extract. The increased levels of lipid peroxidation and hydroperoxides in diabetic rats were reverted back to near normal levels after the treatment with seed kernel extract. Diabetic rats treated with seed kernel extract restored almost normal architecture of liver and kidney and were confirmed by histopathological examination. The present study reveals the efficacy of Eugenia jambolana seed kernel in the amelioration of diabetes, which may be attributed to its hypoglycemic property along with its antioxidant potential. The antioxidant effect of Eugenia jambolana seed kernel was also compared with glibenclamide, a standard hypoglycemic drug.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 27 (8), 1212-1217, 2004

  The Pharmaceutical Society of Japan

Keywords

• antioxidant
• <i>Eugenia jambolana</i> seed kernel
• free radical
• oxidative stress
• streptozotocin diabetes

Details

• CRID: 1390282679604003456
• NII Article ID: 110003608947
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.27.1212
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 7020980
• PubMed: 15305024
• Web Site: http://id.ndl.go.jp/bib/7020980
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7020980
• Web Site: http://www.jstage.jst.go.jp/article/bpb/27/8/27_8_1212/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2005201297
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed