Effect of Camellia Oil on the Permeation of Flurbiprofen and Diclofenac Sodium through Rat and Pig Skin
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- Wang Aiping
- Hokkaido College of Pharmacy Shenyang Pharmaceutical University
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- Seki Toshinobu
- Hokkaido College of Pharmacy
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- Yuan Dan
- Shenyang Pharmaceutical University
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- Saso Yuko
- Hokkaido College of Pharmacy
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- Hosoya Osamu
- Hokkaido College of Pharmacy
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- Chono Sumio
- Hokkaido College of Pharmacy
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- Morimoto Kazuhiro
- Hokkaido College of Pharmacy
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Abstract
The effect of camellia oil on the permeation of flurbiprofen (FP) and diclofenac sodium (DFS), used as model drugs, through rat and pig skin was examined. Two different types of camellia oil were used: one of them was purified by distillation and the other was purified by filtration without heating. The distilled camellia oil (DCO) and the filtered camellia oil (FCO) were applied to the skin as a pretreatment. Permeation of FP through the skins pretreated with FCO and DCO was enhanced, while that of DFS was suppressed. The effects of FCO were greater than those of DCO as far as enhancement and suppression were concerned. The effect of FCO on FP permeation could be due to oleic acid, one of the major components of FCO. On the other hand, FCO and oleic acid had opposite effects on the penetration of DFS. This result suggests that other active components which suppress the permeation of DFS may be present in FCO. Since the penetration-suppressing agents will be useful for skin care products, studies of such agents will be important in the future.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 27 (9), 1476-1479, 2004
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204626086016
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- NII Article ID
- 110003609001
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 7056732
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- PubMed
- 15340244
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed