Sesquiterpene Coumarins from Ferula fukanensis and Nitric Oxide Production Inhibitory Effects (2)

• Motai Tsunetake

  College of Pharmacy, Nihon University

• Kitanaka Susumu

  College of Pharmacy, Nihon University

抄録

Four new sesquiterpene coumarin derivatives, fukanemarin B (1), fukanefuromarin E (2), fukanefuromarin F (3) and fukanefuromarin G (5) were isolated from a 80% aqueous methanol extract of the roots of Ferula fukanensis. The structures were elucidated based on spectral evidence, especially heteronuclear multiple-bond connectivity (HMBC) and high-resolution MS. The 80% aqueous methanol extract of the roots of Ferula fukanensis (FFE) and the sesquiterpene coumarin derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-γ (IFN-γ).

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 52 (10), 1215-1218, 2004

  公益社団法人 日本薬学会

キーワード

• <i>Ferula fukanensis</i>
• sesquiterpene coumarin
• macrophage
• nitric oxide

詳細情報

• CRID: 1390001204168765952
• NII論文ID: 110003615513
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.52.1215
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 7097307
• PubMed: 15467238
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7097307
• Web Site: http://www.jstage.jst.go.jp/article/cpb/52/10/52_10_1215/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006162400
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可