Cyclooxygenase-2 Inhibitory Cerebrosides from Phytolaccae Radix.

• KANG Sam Sik

  Natural Products Research Institute, Seoul National University

• KIM Ju Sun

  Natural Products Research Institute, Seoul National University

• SON Kun Ho

  Department of Food and Nutrition, Andong National University

• KIM Hyun Pyo

  College of Pharmacy, Kangwon National University

• CHANG Hyeun Wook

  College of Pharmacy, Yeungnam University

抄録

A mixture of cerebrosides, called poke-weed cerebrosides, was purified from Phytolaccae Radix (Phytolaccaceae) and characterized as 1-O-β-D-glucopyranosides of phytosphingosine type ceramides comprised of a common long chain base (2S, 3S, 4R, 8Z)-2-amino-8-octadecene-1, 3, 4-triol and fatty acids. The fatty acyl chain of ceramide moieties was determined as (2R)-2-hydroxypentacosanoic acid, (2R)-2-hydroxylignoceric acid, (2R)-2-hydroxytricosanoic acid, (2R)-2-hydroxybehenic acid, (2R)-2-hydroxypalmitic acid, and palmitic acid. The poke-weed cerebroside inhibited the cyclooxygenase-2 dependent phase of prostaglandin D₂ generation in bone marrow-derived mast cells in a concentration dependent manner with an IC₅₀ of 6.2 μg/ml.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 49 (3), 321-323, 2001

  公益社団法人 日本薬学会

キーワード

• Phytolaccae Radix
• Phytolaccaceae
• cerebroside
• cyclooxygenase-2 inhibitor

詳細情報

• CRID: 1390001204160956032
• NII論文ID: 110003615895
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.49.321
• COI: 1:CAS:528:DC%2BD3MXhs1Ohsbw%3D
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 5683053
• PubMed: 11253924
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5683053
• Web Site: http://www.jstage.jst.go.jp/article/cpb/49/3/49_3_321/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001141535
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可